纵向性尿道内与独立的老年人随着时间的推移听力值的变化有关
Rachel L Kidd1, Akosua Agyemang-Prempeh2,3, Alan Sanderson2
1CES, Medicine, B85, University of Southampton, Southampton, SO17 1BJ, UK.
Scientific reports
|June 13, 2024
概括
尿液中的neopterin挥发性可以识别与年龄相关的听力损失和其他健康问题更高风险的老年人. 监测这种炎症标志物可能会改善风险人群的管理.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 听力学 听力学是指听力学.
背景情况:
- 低度慢性炎症与许多与年龄相关的疾病有关,影响老年人的健康结果.
- 需要使用慢性炎症的非侵入性监测方法,以更好地管理处于风险的老年人群.
- 一种代谢物Neopterin作为免疫系统激活和炎症的生物标志物.
研究的目的:
- 调查老年人中素挥发性和与年龄相关的听力损失之间的关联.
- 为了确定质蛋白水平是否可以根据炎症风险对个体进行分层,并预测听力恶化.
- 探索炎症风险类别与其他与年龄有关的疾病的患病率之间的关系.
主要方法:
- 一项纵向队列研究,涉及45名独立的老年人 (65-75岁).
- 在12个月内每月收集尿液样本,以测量质蛋白水平并评估挥发性.
- 在基线,1年和3年时,使用纯色调听力测试来评估听力.
主要成果:
- 处于最高风险类别的个体 (neopterin提升>50%的时间) 显著增加了高频听力损失.
- 在风险类别之间观察到高频听力变化的显著差异 (韦尔奇的ANOVA,p=0.0005).
- 与最低风险组相比,高风险组的患者患上与年龄相关的额外疾病的可能性是最低风险组的两倍多.
结论:
- 尿液中的neopterin挥发性是一种潜在的非侵入性生物标志物,用于分层老年人,有逐渐听力损失的风险.
- 这种方法可以帮助识别容易加速与年龄有关的衰退和增加发病率的个体.
- 监测内素波动性可以帮助为处于风险的老年人群制定主动管理策略.
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