开发,验证和可视化基于网络的诺米图谱,用于预测穿皮冠状动脉干预后新发糖尿病风险
Mengmeng Zhu1,2, Yiwen Li1,2,3, Wenting Wang1,2
1National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No.1 of Xiyuan Caochang, Haidian District, Beijing, 100091, China.
Scientific reports
|June 13, 2024
概括
一个新的在线工具有助于在皮肤冠状动脉干预 (PCI) 后识别患有新发糖尿病高风险的患者. 这种简单的查方法使用常规因素来预测风险并改善患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 医疗信息学 医疗信息学
背景情况:
- 穿皮冠状动脉干预 (PCI) (NODAP) 后新发糖尿病会对患者的预后产生负面影响.
- 对于NODAP,迫切需要简单实用的选工具.
- 识别高风险个体对于及时干预和改善结果至关重要.
研究的目的:
- 为了评估NODAP的风险因素.
- 开发和验证使用常规变量对NODAP风险进行在线预测工具.
- 为PCI后患者创建一个风险分层系统.
主要方法:
- 分析了2698名接受PCI治疗急性冠状动脉综合征的患者的多中心数据库.
- 最小绝对收缩和选择操作员 (LASSO) 回归和物流回归确定了关键预测因素.
- 开发了一个基于网络的nomogram,并通过外部验证来预测NODAP风险.
主要成果:
- 确定了NODAP的五个关键预测因素:空腹血葡萄糖,低密度脂蛋白胆固醇,高血压,糖尿病家族史和利尿剂使用.
- 开发的基于网络的名录显示出良好的区分,校准和临床实用性.
- 该工具准确地将患者分为NODAP的不同风险类别.
结论:
- 一个简单,实用和经过验证的基于Web的nomogram可以有效地选PCI后的NODAP风险.
- 该工具帮助临床医生识别高风险患者并定制管理策略.
- 这种预测工具有可能通过早期干预来改善PCI后患者的预后.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...


