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Updated: Jun 24, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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人类的ATAD5已经进化了独特的结构元素,以专门作为PCNA卸载器发挥作用

Feng Wang1, Qing He1, Nina Y Yao2

  • 1Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.

Nature structural & molecular biology
|June 13, 2024
PubMed
概括

ATAD5-RFC复合物由于其独特的结构特征,仅从DNA中卸载增殖细胞核抗原 (PCNA). 这些特征,包括锁定循环和DNA结合室塞,防止DNA结合,并解释其卸载功能.

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