在糟糕的骨环境中,纳米超和生物活性表面. 第1部分:从初级稳定性过渡到二级稳定性. 一个受控的临床试验:在低密度骨中的生物活性植入物表面
Luigi Canullo1,2, Maria Menini3, Paolo Pesce3
1Department of Surgical Sciences (DISC), University of Genoa, Largo R. Benzi 10, Genoa, 16132, Italy. luigicanullo@yahoo.com.
Clinical oral investigations
|June 13, 2024
概括
生物活性植入物表面增强早期骨愈合和低密度骨 (D3-D4) 的稳定性. 这改善了从初级稳定性过渡到二级稳定性,这对于牙植入物成功至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 骨再生 骨再生
背景情况:
- 生物活性表面被设计为促进细胞相互作用,可能加速生物稳定性和植入物加载协议.
- 优化植入物稳定性对于成功的骨整合至关重要,尤其是在骨损伤的情况下.
研究的目的:
- 评估与传统表面相比,生物活性植入物表面在提高D3-D4骨密度的植入物稳定性方面的有效性.
- 评估生物活性表面对早期骨愈合和实现二次稳定性的影响.
主要方法:
- 一项涉及36名骨密度为D3-D4的患者的比较研究,随机分配接受生物活性 (测试) 或传统 (控制) 表面植入物.
- 在基线,手术后30天和45天使用植入物稳定率 (ISQ) 测量植入物稳定性. 此外,还评估了插入扭矩,累积扭矩,扭矩密度和边缘骨损失.
主要成果:
- 在整个观察期内,生物活性表面组显示出稳定的ISQ值,而对照组显示出显著下降.
- 扭矩密度和ISQ之间的相关性是显著的,在生物活性组中更为明显,特别是在D3骨中.
- 在生物活性组中加载协议的加快是由于早些时候达到所需的ISQ值.
结论:
- 生物活性植入物表面在维护植入物稳定性方面表现出卓越的性能,在D3-D4骨质的骨愈合的早期阶段保持植入物稳定性.
- 生物活性表面的使用有助于更顺地从初级稳定性过渡到二级稳定性,在缺乏骨的环境中提供临床优势.
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