内脏脂质积累和不孕症指标之间的关联:基于美国妇女的横截面研究
Chenyuan Deng1, Xinpeng Ke1, Liangcai Lin1
1Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Lipids in health and disease
|June 13, 2024
概括
像腰围 (WC),内脏脂肪代谢得分 (METS-VF),脂质积累产物 (LAP) 和内脏脂肪指数 (VAI) 这样的内脏脂肪指标与更高的不孕率有关. METS-VF成为最重要的预测因素.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 关于内脏脂肪积累和不孕不育的证据有限且有争议.
- 需要新的内脏脂肪指标来澄清这种关联.
研究的目的:
- 用多个指标调查内脏脂质积累和不孕不育之间的相关性.
- 在内脏脂肪标记物中确定不孕不育的最重要的预测因素.
主要方法:
- 已使用的NHANES 2013-2020数据.
- 使用后勤回归,平滑曲线拟合,子组分析和XGBoost算法.
- 评估腰围 (WC),METS-VF,LAP和VAI与不孕不育有关.
主要成果:
- 所有四个内脏脂肪指标 (WC,METS-VF,LAP,VAI) 都显示出与不孕症的强烈积极关联.
- METS-VF被XGBoost.确定为最有影响力的不孕症因素.
- 亚组分析证实了大多数亚组中一致的相关性.
结论:
- 通过WC,METS-VF,LAP和VAI测量的内脏脂肪增加与更高的不孕症患病率有关.
- 这些发现强调了内脏脂肪在生殖健康中的作用.
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