关于深层虫管理的随机对照试验中CONSORT陈述的坚持和偏差风险:一个元研究
Rokaia Ahmed Elagami1,2, Thais Marchezini Reis1, Mohamed Ahmed Hassan3
1Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University of São Paulo, São Paulo, Brazil.
BMC oral health
|June 13, 2024
概括
关于深层虫管理的随机对照试验显示,人们对CONSORT指南的遵守程度较低,从而增加了偏差风险. 提高报告质量对于可靠的儿科牙科研究至关重要.
科学领域:
- 儿科牙科 儿科牙科
- 临床试验方法论 临床试验方法论
- 基于证据的牙科.
背景情况:
- 深层虫病管理的最新进展需要高质量的研究才能有效实施.
- 现有的随机对照试验 (RCT) 可能缺乏足够的细节,阻碍了解释和临床应用.
- 在RCT中评估报告质量和偏差风险对于推进深层虫病管理至关重要.
研究的目的:
- 评估关于深层虫管理的RCT中遵守"报告试验综合标准" (CONSORT) 声明.
- 评估这些RCT中的偏差风险.
- 确定与CONSORT遵守和偏差风险相关的因素.
主要方法:
- 在PubMed的系统搜索中,在儿科牙科期刊 (2010-2022) 中确定了关于深病管理的RCT.
- 通过修改的19项工具和Cochrane RoB 2工具评估了CONSORT的坚持和偏差风险.
- 进行了描述和回归分析,以评估报告质量和偏差.
主要成果:
- 分析了127个RCT,平均CONSORT坚持得分为21.1 (SD 6.7).
- 对于"干预"报告 (96.1%) 值得注意的是高的坚持,但对于"估计效果大小" (83.5%得分为0) 值得注意的是低的坚持.
- 40.2%的RCT被评估为具有高偏差风险的RCT,这与较低的CONSORT分数和非CONSORT认可期刊上的出版相关. 较旧的试验也显示了较低的遵守.
结论:
- 在儿科深层虫管理RCT中遵守CONSORT报告准则是不理想的.
- 较低的CONSORT坚持与偏差风险增加显著相关.
- 改善对报告准则的遵守对于提高该领域研究的可靠性和有效性至关重要.
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