在患有牛皮关节炎的患者中,对脂蛋白及其子分量的营养影响:一项为期12周的随机试验 - - DIETA试验
Daniele Scherer1, Beatriz Figueiredo Leite1, Melissa Aparecida Morimoto1
1Rheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Advances in rheumatology (London, England)
|June 13, 2024
概括
牛皮关节炎患者通常具有不健康的脂质样本,增加心血管风险. 12周的omega-3脂肪酸和饮食干预改善了大型HDL颗粒,这表明有针对性的营养方法来管理PSA的心血管风险.
科学领域:
- 心血管健康 心血管健康
- 类风湿病学 类风湿病学
- 营养科学 营养科学
背景情况:
- 牛皮关节炎 (PsA) 与改变的脂质代谢和心血管疾病 (CVD) 风险增加有关,独立于传统因素.
- 在PsA中,慢性炎症可能会导致动脉样硬化,但特定的动脉样和脂蛋白分片未得到充分研究.
- 识别高心血管风险的PsA个体对于预防策略至关重要.
研究的目的:
- 在PSA患者12周的营养干预后,评估高密度脂蛋白 (HDL) 和低密度脂蛋白 (LDL) 胆固醇分片的变化.
- 为了评估饮食和omega-3脂肪酸补充剂对PsA.在PSA中的异位性脂蛋白样本的影响.
- 为了确定营养干预是否可以修改与心血管风险相关的脂蛋白分片在PSA.
主要方法:
- 一个为期12周的随机化,安慰剂控制试验,涉及91名PsA患者.
- 干预组包括安慰剂 (大豆油),饮食加omega-3补充剂和饮食加安慰剂.
- 脂蛋白分片 (LDL:非致动性,致动性,高度致动性;HDL:小,中,大) 通过电泳分析.
主要成果:
- 62%的PsA患者表现出异位性或高度异位性LDL概况,与男性性别,更长的疾病持续时间和更高的BMI有关.
- 35%的人有高风险脂蛋白形状,尽管LDL水平低于100 mg/dL.
- 12周的干预措施没有改变LDL亚分数,但显著改善了HDL亚分数,特别是大型HDL粒子.
结论:
- 识别亲动脉产生性LDL亚分数是评估PsA心血管风险的关键,无论LDL总水平如何.
- 用omega-3脂肪酸进行的营养干预对PsA患者的大型HDL亚分数产生了积极的影响.
- 监督,个性化的饮食与omega-3s相结合,有望改善心血管风险标志物.
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