微RNA-98:在人类癌症进展和治疗中的多方面的调节器
Vajihe Hazari1, Sahar Ahmad Samali2, Payam Izadpanahi3
1Department of Obstetrics and Gynecology, School of Medicine, Rooyesh Infertility Center, Birjand University of Medical Sciences, Birjand, Iran.
Cancer cell international
|June 13, 2024
概括
微RNA-98 (miR-98) 在癌症中具有双重作用,既起瘤促进作用,又起瘤抑制作用. 了解 miR-98 的理解
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 微RNA,包括microRNA-98 (miR-98),是癌症研究中至关重要的小型非编码RNA.
- miR-98在瘤发生,转移和癌症治疗中起着重要作用.
- 它的功能扩展到调节关键的细胞过程,如增殖,细胞亡和细胞循环.
研究的目的:
- 对miR-98的生物发生,分子性质和癌症中的功能进行全面的审查.
- 为了突出miR-98作为瘤促进剂和抑制剂的双重作用.
- 探索miR-98作为诊断和预后生物标志物的潜力,并评估治疗策略.
主要方法:
- 文献综述综合了在瘤学中对miR-98的当前研究.
- 对miR-98参与癌症进展和细胞功能的分析.
- 对miR-98.8的诊断,预后和治疗影响的评估.
主要成果:
- miR-98在癌症中表现出一种上下文依赖的双重作用,既起瘤促进作用,又起瘤抑制作用.
- miR-98影响癌症的关键特征,包括增殖,细胞亡和细胞循环调节.
- 表达模式表明miR-98在液体活检和瘤组织中作为生物标记物的潜力,尽管临床翻译面临障碍.
结论:
- miR-98为癌症诊断和治疗提供了有前途的途径.
- 需要进一步的研究来了解miR-98在瘤-肌瘤相互作用,免疫调节和代谢调节中的作用,以改善癌症管理.
- 克服治疗耐药性的挑战对于基于miR-98的有效干预至关重要.
相关概念视频
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
02:23Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K