门诊精神病学中的抗抑郁药物处方模式和多药学:一个横截面研究
M S R Al Zaabi1, S B Sridhar1, S A Rabbani1
1Department of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences University.
Die Pharmazie
|June 14, 2024
概括
选择性血清素再吸收抑制剂 (SSRI) 是最常被处方的抗抑郁药,通常用于单一治疗. 然而,精神病学多药制是普遍存在的,许多患者接受多种精神药物,需要仔细监测.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 抗抑郁药物处方模式不断发展,有利于使用具有更好的安全性和耐受性的新药.
- 多药是精神病医疗机构中经常发生的情况.
- 了解当前抗抑郁药的使用和多药学对于优化患者的治疗结果至关重要.
研究的目的:
- 为了分析精神病诊所的抗抑郁药物处方模式.
- 在这种环境中评估多药学的范围和特征.
- 评估相对于定义的每日剂量 (DDD) 的规定每日剂量 (PDD).
主要方法:
- 在精神病室门诊中进行前性观察性研究.
- 从131名患者收集和分析药物使用数据.
- 使用标准化框架评估处方理由,DDD,PDD,PDD/DDD比率和多药.
主要成果:
- 重度抑郁症是最常见的抗抑郁药处方 (32.8%).
- 选择性血清素再吸收抑制剂 (SSRI) 是最常见的类别 (52.7%),米尔塔扎是最常见的个人药物 (24.4%).
- 在87.1%的处方中记录了精神病多药,抗精神病药物经常被共同处方 (37.4%).
结论:
- 在单疗法和组合疗法中,SSRI主导了抗抑郁药的处方.
- 高水平的多药,包括同时使用抗抑郁药和其他精神药物,需要警的临床监督.
- PDD/DDD比率有所变化,米尔塔扎和伊米普拉低于1,这表明潜在的剂量不足或特定的处方做法.
更多相关视频
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
220
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
220
01:25Antidepressant Drugs: Overview
439
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
439
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
364
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
364
01:28Drug Therapy
42
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
42
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
120
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
120
01:02Prescription, Nonprescription and Orphan Drugs
719
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
719