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(近) 皮层病变的亚型和位置与多发性硬化症患者的认知功能障碍有关
Eva A Krijnen1,2, Rose-Marie Kouwenhoven1, Samantha Noteboom1
1MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
概括
白皮质病变在多发性硬化 (MS) 与认知障碍 (CI) 中很常见,但皮质内病变特别区分认知能力. 灰质病变的参与是MS认知的关键.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 神经科学是一个神经科学.
背景情况:
- 认知障碍 (CI) 是多发性硬化症 (MS) 的一个重大挑战.
- 了解皮层病变亚型和CI之间的关系对于MS患者的治疗至关重要.
- 大脑网络中的病变分布和类型可能会影响认知功能.
研究的目的:
- 研究不同皮层病变亚型 (皮层内,皮层外,皮层下) 与MS患者认知障碍之间的关联.
- 确定病变的位置和类型是否与特定的认知缺陷相关.
- 为了比较病变特征对相对于MS表型的认知的影响.
主要方法:
- 对332名多发性硬化症患者的人工生成的双反转恢复磁共振图像的分析.
- 皮层病变的分类为皮层内皮层,皮层外皮层和皮层下皮层亚型.
- 统计分析以评估不同网络中的损伤数量与认知表现之间的关系.
主要成果:
- 在CI患者的感觉运动和认知网络中,白皮层病变的数量显著增加 (p < 0.001).
- 只有皮层内病变数量才能区分认知性能组 (p = 0.024).
- 损伤数量对认知的影响大小比MS表型之间观察到的差异大得多 (2至4倍).
结论:
- 白皮层病变在患有认知障碍的多发性硬化症中占主导地位.
- 皮层内病变是区分多发性硬化群体内认知群体的关键指标.
- 病变对灰质的参与似乎是决定MS认知结果的关键因素,可能比整体疾病负担更重要.
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