细胞癌和第二次原发性癌症的风险:丹麦全国性队列研究
Maria B Bengtsen1,2, Dóra K Farkas1,2, Henrik T Sørensen1,2
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Cancer medicine
|June 14, 2024
概括
患有癌 (细胞癌) 的患者面临着持续增长40%的第二种原发性癌症的风险. 这种高风险,特别是肺癌和膀癌,在初始诊断后长期持续存在.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 细胞癌 (RCC) 是一个重要的癌症诊断.
- 了解初步癌症诊断的长期影响对于患者管理和公共卫生至关重要.
- 在初始诊断后,患上后续原发性癌症的风险需要进行彻底的调查.
研究的目的:
- 在被诊断患有突发性细胞癌 (RCC) 的个人中调查第二次原发性癌症的风险.
- 量化RCC后的第二种原发性癌症的绝对风险和标准化发病率 (SIR).
- 确定导致RCC患者风险增加的特定癌症类型.
主要方法:
- 利用基于人口的丹麦医疗登记册来识别1995-2019年间发生RCC的患者.
- 采用从RCC诊断到第二次癌症诊断,死亡,移民或2019年底的随访方法.
- 计算绝对风险,SIR和第二次原发性癌症的绝对风险过剩,将RCC患者与一般人群进行比较.
主要成果:
- 任何第二种原发性癌症的1年和20年绝对风险分别为2.8%和17.8%.
- 在RCC诊断后的第一年内,每1000人年有20例癌症病例的过度风险被观察到 (SIR,2.3).
- 持续增加的风险,特别是肺癌和膀癌,在第一年的随访后被注意到.
结论:
- 发生RCC的患者长期患第二种原发性癌症的风险持续增加40%.
- 增加的风险主要与随后的肺癌和膀癌的诊断有关.
- 这一发现强调了对RCC幸存者的二次恶性瘤的长期监测的重要性.
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