通过血清费里素测量日本全血献血者的铁缺乏症
Takeshi Odajima1, Nelson H Tsuno1,2, Fumihiko Ishimaru3
1Japanese Red Cross Central Blood Institute, Tokyo, Japan.
Vox sanguinis
|June 14, 2024
概括
铁缺乏症是日本献血者,特别是女性的一个重大问题,献血后的病例增加. 需要采取进一步的预防措施,以确保供体健康和血液供应安全.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 捐赠者管理的管理.
背景情况:
- 日本的献血政策限制全血 (WB) 献血为400毫升,每年两次为女性,三次为男性.
- 之前的研究表明,在女性捐赠者中,缺铁率很高 (捐赠前20.5%,捐赠后37.7%).
- 20多年过去了,需要对目前关于捐赠铁的情况进行更新评估.
研究的目的:
- 调查目前在日本献血者中缺铁的流行情况.
- 为了比较第一次/重新激活 (FT/RA) 捐赠者和重复捐赠者之间的铁状况.
- 分析基于性别,年龄和更年期状态的铁缺乏趋势.
主要方法:
- 一项涉及2659名WB捐赠者 (1496名男性,1163名女性) 的研究,捐赠了400毫升WB.
- 在FT/RA和重复捐献者之间测量和比较血清费里丁 (sFer) 水平.
- 捐赠者按性别,年龄和更年期状况分层,并对随后的捐赠进行跟踪.
主要成果:
- 大约三分之一的FT/RA女性捐献者表现出缺铁,与一般人口趋势保持一致.
- 绝经前的FT/RA女性捐赠者具有较低的sFer水平,类似于重复捐赠者;然而,绝经后的女性和大多数男性年龄组出现了显著差异.
- 与最初sFer水平正常的捐赠者 (≥26 ng/mL) 相比,初始sFer水平较低的捐赠者恢复得更快.
结论:
- 女性献血者甚至在献血之前都患有铁缺乏症,与历史数据相比,观察到的增加.
- 积极的战略对于预防献血者缺铁是必不可少的.
- 日本正在进行的研究旨在解决这些发现,并改进捐赠者健康协议.
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