在乌克兰的Dnipro战伤中的细菌的表型和基因组分析
Dmytro Stepanskyi1, Oksana Ishchenko1, Ting Luo2
1Department of Microbiology, Virology, Immunology, Epidemiology and Biomedical Physics and Informatics, Dnipro State Medical University, Dnipro, Ukraine.
JAC-antimicrobial resistance
|June 14, 2024
概括
抗生素耐药的细菌,包括产生卡巴酶的菌株,正在感染乌克兰受伤的军人. 这些危险的病原体在医疗疏散期间很早就被获得了,这突显了迫切的公共卫生问题.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 抗生素耐药性对全球健康构成重大威胁,特别是在冲突地区.
- 乌克兰受伤的军人容易感染抗生素耐药细菌的感染.
- 了解传播途径对于有效的治疗和预防至关重要.
研究的目的:
- 在乌克兰有战争伤口的军人中调查抗生素耐药细菌的来源和传播途径.
- 描述这些病原体的表型和基因组特征.
主要方法:
- 在德尼普罗的一家中等疏散医院从战争伤口中收集和培养了11种格拉姆阴性细菌病原体.
- 对分离的菌株进行了表型和基因组分析.
主要成果:
- 在分离物中确定了敏感和广泛耐药的菌株.
- 检测到携带carbapenemases的高风险全球克隆,表明存在强大的抗药机制.
- 证实了全球分布的碳烯酶生产系的早期获取.
结论:
- 在乌克兰,具有全球意义的抗生素耐药性细菌,包括碳酶生产者,在医疗疏散链的早期被获得.
- 这种早期获取对受伤的军人治疗和结果构成重大风险.
- 调查结果强调,需要在军事医疗疏散系统中加强感染控制措施.
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