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通过抑制与自相关的蛋白质VPS34改善基于STING激动剂的癌症疗法

Elisabetta Bartolini1, Kris Van Moer1, Bassam Janji1

  • 1Tumor Immunotherapy and Microenvironment (TIME) group, Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.

Oncoimmunology
|June 14, 2024
PubMed
概括

抑制VPS34可以通过cGAS/STING通路增加T细胞的招募. 将VPS34抑制剂与STING激动剂ADU-S100结合起来,可以增强细胞因子的释放和小鼠的瘤控制.

关键词:
自自是一种自的过程.CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5CD8 T 细胞 CD8 T 细胞在CXCL10中,CXCL10是CXCL10中的一个.在 NK 细胞中,NK 细胞是 NK 细胞.这就是PIK3C3C3的意思.刺痛激动剂 刺痛激动剂 刺痛激动剂这是VPS34的VPS34.免疫疗法 免疫疗法黑色素瘤是一种黑色素瘤.细胞癌瘤是细胞癌.第一种类型的IFN响应.

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