血生长分化因子15水平与中国子宫前之间存在关联
Shuhong Xu1, Yicheng Lu2, Mengxin Yao2
1Taicang Affiliated Hospital of Soochow University, The First People's Hospital of TaiCang Soochow University Suzhou Jiangsu China.
Chronic diseases and translational medicine
|June 14, 2024
概括
孕妇中生长差异化因子-15 (GDF-15) 的较高水平与妊娠前 (PE) 的风险增加有关. GDF-15可能是诊断PE的有用生物标志物.
科学领域:
- 生物化学 生物化学
- 生殖医学 生殖医学
- 心血管健康 心血管健康
背景情况:
- 增长差异化因子-15 (GDF-15) 是一种应激反应蛋白,与心血管疾病 (CVD) 有关.
- 需要进一步调查GDF-15和妊娠前 (PE) 之间的关系,这是一个严重的妊娠并发症.
研究的目的:
- 调查血清GDF-15水平与子宫前 (PE) 的发生之间的关联.
- 评估GDF-15作为PE诊断生物标志物的潜力.
主要方法:
- 在299名孕妇中使用ELISA量化母体血清GDF-15水平 (63名PE,236名对照).
- GDF-15水平表达为中位数 (MOM) 的倍数,以正常化妊娠年龄.
- 使用后勤回归模型来评估GDF-15 MOM和PE风险之间的关联,并对共变量进行调整.
主要成果:
- 血清GDF-15MOM在患有PE的妇女中明显高于正常怀孕的妇女 (1.588比1.000,p<0.001).
- 增加的GDF-15 MOM (>1) 与PE风险增加4.74倍 (95% CI = 2.23-10.08,p < 0.001),即使经过对混因素进行调整.
结论:
- 较高的血清GDF-15水平与子宫前显著相关.
- GDF-15显示出作为一种有价值的生物标志物,用于早期诊断PE的潜力.
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