用植物提取物优化帕金森病治疗和营养的演变角色
Patrick Oluwole Abolarin1, Abdulbasit Amin1, Abdulrazaq Bidemi Nafiu2
1Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
IBRO neuroscience reports
|June 14, 2024
概括
营养和植物提取物在通过向关键病理途径来管理帕金森病 (PD) 方面表现有前途. 这些天然化合物提供了作为补充疗法的潜力,以改善患者的生活质量.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 帕金森病 (PD) 涉及多巴胺基神经元的退化,导致运动和非运动症状.
- 病变发生与氧化应激,神经炎症,线粒体功能障碍和蛋白质聚合有关.
- 目前的药理疗法存在局限性,对补充方法的兴趣越来越大.
研究的目的:
- 审查营养和植物提取物在治疗帕金森病中的作用.
- 在PD中分析食化合物和植物的神经保护机制.
- 讨论将临床前发现转化为临床实践的挑战.
主要方法:
- 对PD中营养和植物提取物的现有文献进行系统审查.
- 对研究对PD症状和进展的影响的研究分析.
- 对维生素和植物化学品等营养品的检查,包括Mucuna pruriens.
主要成果:
- 营养药和植物化学品在临床前和临床研究中显示出神经保护的潜力.
- 这些药物可以改善线粒体功能障碍,氧化应激和神经炎症.
- 花因其潜在的治疗益处而受到重视.
结论:
- 营养和植物提取物显示出作为帕金森病辅助疗法的前景.
- 这些策略针对涉及到PD病变的多个途径.
- 需要进一步的研究来应对标准化,生物可用性和可变性等挑战.
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