伦瓦提尼布结合跨动脉化学栓塞 vs. 索拉芬尼布结合跨动脉化学栓塞治疗不可切除的肝细胞癌:一个网络的元分析
Yong Li1, Xingyu Liu1, Junning Liu1
1Department of Hepato-Biliary-Pancrease II, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Oncology letters
|June 14, 2024
概括
与索拉芬尼布加TACE相比,伦瓦替尼布加跨动脉化血栓化 (TACE) 对不可切除的肝细胞癌 (uHCC) 显示出更高的疗效. 这种组合疗法为HHCC患者提供了改善的生存率和反应率.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 干预性放射学 干预性放射学
- 医学瘤学 医学瘤学
背景情况:
- 通过动脉化学栓塞 (TACE) 与铁氨酸激酶抑制剂相结合是不可切除的肝细胞癌 (uHCC) 的标准.
- 仅有有限的数据比较lenvatinib或sorafenib与TACE结合治疗HHCC.
研究的目的:
- 系统地比较TACE与伦瓦提尼布相结合的疗效与HHCC的索拉芬尼布.
- 评估单独治疗的伦瓦提尼布或索拉费尼布与它们各自的TACE组合.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆的系统文献搜索.
- 八项随机对照试验的网络元分析,涉及2929名患者.
- 分析整体存活率,无进展存活率,客观反应和疾病控制率.
主要成果:
- 伦瓦提尼布加TACE证明了最大整体存活率 (97.92%),无进展存活率 (87.8%),客观反应 (96.68%) 和疾病控制 (96.27%).
- 与索拉芬尼布加TACE相比,伦瓦替尼布加TACE在HHCC中显著提高了疗效.
- 该研究分析了95%置信区间的危险比率和风险比率.
结论:
- 与索拉芬尼布加TACE相比,伦瓦替尼布加TACE是对HHCC的潜在优越治疗选择.
- 林瓦提尼布和TACE的组合疗法可能是 uHCC管理的优先选择.
- 进一步的研究应该在临床实践中证实这些发现.
更多相关视频
09:11Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
409
09:49Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Published on: December 2, 2013
10.3K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K