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相关概念视频

Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.9K

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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

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绘制人类血液构成分化的表皮化动态图.

Xiaohuan Qin1, Jiayi Lu1, Peng Wu1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Department of Stem Cell and Regenerative Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Blood science (Baltimore, Md.)
|June 14, 2024
PubMed
概括

表皮突变,DNA甲基化变异,显著影响血细胞发育和疾病. 我们的研究绘制了这些表观遗传变化的地图,揭示了它们在人类血液形成中的关键作用,并提供了新的见解.

关键词:
通过DNA甲基化.标记化 (Epimutation) 是一种表达方式.血液构成分化的分化.造血干细胞是造血干细胞的组成部分.

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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相关实验视频

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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 分子生物学分子生物学
  • 血液学 血液学 血液学

背景情况:

  • DNA甲基化对于造血细胞的分化至关重要.
  • 表皮突变引入了表皮遗传异质性,但它们在血液形成和疾病中的作用尚不清楚.

研究的目的:

  • 开发一种用于量化表皮图的工具.
  • 为了研究人类造血细胞分化过程中的表皮图景.
  • 探索血造干细胞和急性髓性白血病中表皮细胞的作用.

主要方法:

  • 开发了Julia包EpiMut,用于快速准确的表皮质量定量.
  • 分析了从干细胞到成熟细胞的13种血细胞类型的表皮图景.
  • 在造血干细胞和急性髓性白血病中研究了表皮.

主要成果:

  • 在差异化过程中在基因组区域中确定了大量的表观遗传变异.
  • 在血统分化过程中观察到阶段性表皮动力学.
  • 发现了与血统差异化相关的丰富信号的表皮.
  • 血造干细胞和急性髓性白血病中的表皮切除与细胞功能和疾病有关.

结论:

  • EpiMut提供了人类血液形成的综合性表皮图.
  • 表皮转移在正常的造血调节和恶性疾病中起着重要作用.
  • 这项研究为管理血细胞发育的表观遗传机制提供了新的见解.