慢性炎症性肠道病变中的超结构性变化 - - 狗和人类之间的比较
Simone A Fietz1, Mirjam Kalusa1, Albert E Jergens2
1Institute of Anatomy, Histology and Embryology, College of Veterinary Medicine, Leipzig University, Leipzig, Saxony, Germany.
Frontiers in cell and developmental biology
|June 14, 2024
概括
在慢性炎症性肠道病 (CIEs) 中对犬类粘膜的超结构评估可能会提供更敏感的诊断方法. 这种方法可以在患有CIE的狗中临床和组织学缓解之前或在临床和组织学缓解后持续.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
背景情况:
- 慢性炎症性肠道病 (CIE) 是一种复杂的犬病.
- 目前的诊断方法如内镜和组织病理学在分类CIEs和预测治疗反应方面存在局限性.
- 粘膜疾病的治愈和超结构性评估在狗CIE中没有得到研究.
研究的目的:
- 评估关于犬类CIE和人类炎症性肠病 (IBD) 的超结构性粘膜病变的文献.
- 突出超结构性评估作为犬类CIE敏感诊断工具的潜力.
- 建议未来的研究方向,研究犬类CIE的超结构性粘膜病变.
主要方法:
- 文献综述和现有研究的综合研究对超结构性病变在狗CIE和人类IBD.
- 对犬类CIE和人类IBD之间的超结构性发现进行比较分析.
主要成果:
- 狗CIE是人类IBD的一个有价值的自发模型.
- 与光显微镜相比,超结构性粘膜病变的检测灵敏度可能更高.
- 这些超结构性变化可能会在临床和组织学解决后发生或持续.
结论:
- 对犬类粘膜的超结构性评估需要进一步调查,以便进行CIE诊断和监测.
- 这种方法可以更深入地了解疾病的发病和缓解.
- 未来的研究应侧重于犬类CIE中超结构性粘膜病变的诊断和预后价值.
相关概念视频
Chronic Bowel Disorders: Introduction
440
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
440
Inflammatory Bowel Disease II: Crohn's Disease
213
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
213
Inflammatory Bowel Disease I: Ulcerative Colitis
161
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
161
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Chronic Pancreatitis I: Introduction
86
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
86


