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脂质积累产品指数和慢性病之间的关联:系统性审查和元分析
Feixiang Wu1, Chenmin Cui2, Junping Wu1
1Department of Endocrinology and Nephrology, Hangzhou Linping District Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang 311199, P.R. China.
Experimental and therapeutic medicine
|June 14, 2024
概括
脂质积累产品 (LAP) 指数显示,与慢性病 (CKD) 有着适度的联系. 这种关联在非糖尿病患者中更强烈,这表明LAP指数在CKD风险评估中有用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病和脂质失调是慢性病 (CKD) 的重要危险因素.
- 脂质积累产品 (LAP) 指数是脂质积累的新兴标志物,有可能在CKD风险分层中发挥作用.
- 了解LAP指数与CKD的关联,特别是在糖尿病和非糖尿病人群中,至关重要.
研究的目的:
- 进行一项元分析,评估LAP指数与CKD之间的关联.
- 调查LAP指数对糖尿病患者与非糖尿病人的CKD风险的影响差异.
- 评估LAP指数用于CKD检测的诊断准确度.
主要方法:
- 在主要的科学数据库 (PubMed/MEDLINE,Scopus,Cochrane Library,ScienceDirect,Google Scholar) 中进行了系统的文献搜索.
- 对17项研究进行了元分析,使用随机效应模型计算聚合几率比率 (ORs).
- 通过总结接收器操作特征 (ROC) 曲线,计算曲线下的面积 (AUROC),灵敏度和特异性来评估诊断准确度.
主要成果:
- 较高的LAP指数水平与CKD之间的关联的整体聚合OR为1.098,表明存在温和但显著的联系.
- 亚组分析显示,与糖尿病患者 (OR=1.018) 相比,非糖尿病患者 (OR=2.422) 的相关性要强得多.
- LAP指数显示慢性脏病的诊断准确度中等,AUROC为0.64,灵敏度为0.58,特异性为0.63.
结论:
- 实际上,LAP指数与CKD的相关性很小,在非糖尿病人群中观察到的相关性更强.
- 虽然它的诊断准确度是中等的,但LAP指数可以作为CKD风险分层工具中一个有价值的组件.
- 将LAP指数与其他临床标志物的整合可以提高其在识别患有CKD风险的个人的有用性.
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