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Updated: Jun 24, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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由同位素尿素催化酶酶选择性 [2 + 2] 循环添加生成的β-乳酸子的脱皮化DykAT

Aífe Conboy1, Alister S Goodfellow1, Kevin Kasten1

  • 1EaStCHEM, School of Chemistry, University of St Andrews St Andrews Fife KY16 9ST UK ads10@st-andrews.ac.uk mb105@st-andrews.ac.uk.

Chemical science
|June 14, 2024
PubMed
概括

这项研究引入了一种新的方法,用于使用enantioselective isothiourea催化生成螺旋环β-乳酸. 该过程实现了高的反反选择性,并通过随后的环开放,通过动态动态非对称转换通过出色的立体控制产生β-胺.

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A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species08:12

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Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
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Preparation of Epoxides

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Epoxides that are three-membered ring systems are more reactive than other cyclic and acyclic ethers. The high reactivity of epoxides originates from the strain present in the ring. This ring strain acts as a driving force for epoxides to undergo ring-opening reactions either with halogen acids or weak nucleophiles in the presence of mild acid. The acid catalyst converts the epoxide oxygen, a poor leaving group, into an oxonium ion, a better leaving group, making the reaction feasible. The...
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