在患有血液性恶性瘤的患者中,高尿素血和高尿素尿症的患病率和危险因素
Thanaput Kunlayawutipong1, Thanawat Rattanathammethee2, Teerachat Punnachet2
1Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Frontiers in medicine
|June 14, 2024
概括
淋巴瘤和骨髓扩散性瘤 (MPN),特别是MPN中,高尿素血常见. 功能和乳酸脱酶水平等关键因素与高尿酸水平有关,指导潜在的治疗方法.
科学领域:
- 血液学 血液学 血液学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
背景情况:
- 超尿血是血液恶性瘤的常见并发症.
- 此前对这一群体的高尿尿素尿症的研究产生了相互矛盾的结果.
- 这项研究调查了淋巴瘤和骨髓增殖性新生瘤 (MPN) 中的高尿路血和高尿路尿路血.
研究的目的:
- 为了确定新诊断的淋巴瘤和MPN的患者中高尿素血和高尿素尿的患病率.
- 确定与血清尿酸 (SUA) 和尿液尿酸 (UUA) 水平相关的临床参数.
- 确定这些患者群体中高尿素血和高尿素尿尿症的独立风险因素.
主要方法:
- 对新诊断的淋巴瘤和MPN的成年患者进行横截面研究.
- 临床特征的收集.
- 多重逻辑回归分析,以确定高尿素血和高尿素的独立风险因素.
主要成果:
- 在研究队列 (n=165) 中,高尿路血症的患病率为43.6%,高尿路尿路血症的患病率为39.4%.
- 患有MPN患者 (71.6%) 的超尿血病率高于淋巴瘤患者 (20.9%).
- 在淋巴瘤中,降低的EGFR和升高的LDH与高尿素血症有关;升高的LDH与高尿素尿相关. 在MPN中,低血红蛋白和非常高的LDH是高尿素的危险因素.
结论:
- 高尿路血常见于血液性恶性瘤,特别是MPN.
- 确定了与淋巴瘤和MPN患者的高尿尿素尿症相关的特定临床参数.
- 这些发现可能会为风险分层和管理策略提供信息,包括在高风险患者中使用阿洛普林醇.
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