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在伊朗的Mycobacterium结核病中德拉曼尼德和贝达基林耐药性模式:横截面分析

AmirHossein Akbari Aghababa¹, Mohammad Javad Nasiri^1,2, Parviz Pakzad¹

¹Department of Microbiology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.

New microbes and new infections

|June 14, 2024

概括

在伊朗的多药耐药结核病 (MDR-TB) 中出现德拉曼尼德 (DLM) 耐药性与ddn基因的突变有关. 虽然贝达基林 (BDQ) 仍然有效,但DLM耐药性需要持续监测和研究以控制结核病.

科学领域:

微生物学微生物学
遗传学是一个遗传学.
公共卫生公共卫生

背景情况:

耐多药结核病 (MDR-TB) 是一个重大的全球卫生挑战.
伊朗对德拉曼尼德 (DLM) 和贝达基林 (BDQ) 等新药的新兴耐药性需要紧急调查.

研究的目的:

研究伊朗MDR-TB分离物中对DLM和BDQ药物耐药性的流行率和遗传基础.
确定与对这些关键抗结核药物耐药性相关的特定基因突变.

主要方法:

从五个伊朗结核病实验室收集了38种MDR-TB菌株.
进行异型药物敏感性测试 (DST) 检测异亚,利芬素,乙胺醇,DLM和BDQ.
利用测序来分析DLM (ddn,fgd1) 和BDQ (Rv0678,atpE,pepQ) 抗性相关基因中的突变.

主要成果:

18.5% (7/38) 的MDR-TB分离体对DLM表现出耐药性;所有人仍然对BDQ敏感.
在DDN基因中发生的突变,包括非同义变化和框架转移突变,在DLM耐药分离物中普遍存在.
在57.1%的DLM耐药分离物中发现了一种常见的突变,ddn中的Gly81Ser. 在BDQ抗性相关基因中没有发现任何显著突变.

结论:

伊朗MDR-TB菌株中正在出现德拉曼尼德耐药性,主要是由ddn基因的突变驱动的.
贝达基林保持有效性,但DLM耐药性强调了需要持续监测耐药性的必要性.
鉴于这些发现,对抗药性机制和战略性结核病控制的进一步研究至关重要.

关键词:

抗微生物耐药性抗微生物耐药性贝达奎林是什么意思?贝达奎林是什么意思?德拉曼尼德 (Delamanid) 是一种药物.多种药物耐药性多种药物耐药性结核病菌菌菌的结核病菌的结核病菌.

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