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Updated: Jun 24, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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设计,合成和抗癌评价新型库马林/提亚类同源作为具有分子动态的潜在CDK2抑制剂

Samir Bondock1, Nada Alabbad1, Aisha Hossan1

  • 1Chemistry Department, Faculty of Science, King Khalid University 9004 Abha Saudi Arabia bondock@kku.edu.sa bondock@mans.edu.eg.

RSC advances
|June 14, 2024
PubMed
概括

新型库马林-提亚化合物通过抑制循环素依赖激酶2 (CDK2) 来显示出作为抗癌剂的前景. 衍生6c对HepG2和HCT116癌细胞系表现出强大的抗癌活性.

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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