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饮食成分对多发性硬化症风险和严重性的因果关系:孟德尔的随机化研究

¹Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Frontiers in nutrition

|June 14, 2024

概括

这项研究使用了门德尔的随机化来研究饮食和多发性硬化症 (MS). 增加谷物,维生素C,叶酸和鱼油摄入量可能会降低多发性硬化风险,而减少猪肉和酒精摄入量可以降低多发性硬化风险和严重程度.

科学领域:

营养流行病学营养流行病学
遗传流行病学遗传流行病学
神经免疫学神经免疫学

背景情况:

观察性研究表明饮食影响多发性硬化症 (MS) 风险,但因果关系尚不清楚.
不一致的发现需要强有力的方法来确定MS的饮食因果关系.

研究的目的:

调查基因预测的饮食成分与多发性硬化症的风险和严重程度之间的因果关系.
利用两个样本的门德尔随机化来评估饮食对MS的影响.

主要方法:

采用双样本的孟德尔随机化分析.
在30种来自大规模全基因组关联研究 (GWAS) 的饮食成分中利用了遗传仪器.
从国际多发性硬化遗传学联盟获得的MS风险和严重程度GWAS数据.

主要成果:

基因预测较高的猪肉摄入量与MS风险增加有关 (OR = 6.76).
较高的谷物,维生素C补充剂,叶酸补充剂和鱼油补充剂摄入量与MS风险降低有关.
较高的酒精摄入量与MS严重程度的增加有关,而叶酸补充剂与MS严重程度的降低有关.

结论:

饮食因素,包括谷物,维生素C,叶酸和鱼油,可能在MS中发挥保护作用.
减少猪肉和酒精消费可能有利于MS的预防和治疗.
这些发现支持开发MS的饮食干预措施.

关键词:

门德尔的随机化研究.饮食中的饮食性饮食多发性硬化症多发性硬化症危险的风险危险的风险严重程度的严重程度.

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