口腔菌微生物生态系统的干扰影响了常见变量免疫缺陷急性呼吸道感染的风险
Federica Pulvirenti1, Maria Giufrè2, Tancredi M Pentimalli3,4
1Reference Center for Primary Immune Deficiencies, Azienda Ospedaliero Universitaria (AOU) Policlinico Umberto I, Rome, Italy.
Frontiers in immunology
|June 14, 2024
概括
常见变性免疫缺陷 (CVID) 患者表现出改变的口腔微生物组,多样性减少,潜在有害细菌增加. 这种失生症与CVID中的临床因素和急性呼吸道感染有关.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 呼吸道微生物群对健康至关重要,受遗传学,生活方式和环境的影响.
- 常见变性免疫缺陷 (CVID) 患者面临复发性感染和慢性疾病,对其呼吸道微生物群的理解有限.
- 目前对CVID微生物群的研究主要集中在肠道,而呼吸道微生物群则未得到充分研究.
研究的目的:
- 为了研究CVID的成年人口腔的细菌组成.
- 在CVID患者中,与临床和免疫学特征相关联口腔管微生物组变化.
- 评估呼吸道微生物组失调与CVID中急性呼吸道感染风险之间的关联.
主要方法:
- 在12个月内,从72名CVID成年人和26名对照人群收集了口腔样.
- 甲基因组16S rRNA测序和微生物生态学的定量洞察 (QIME) 管道用于细菌分析.
- 开发了一个失生指数,机器学习模型评估了微生物组在区分CVID患者与对照者的能力.
主要成果:
- 与对照人群相比,CVID患者的口腔大微生物群的α和β多样性较低.
- 在CVID患者中,增加了*Lactobacillales*和*Streptococcaceae*的丰度.
- 降低的α多样性与年龄>45,COPD,IgA缺乏和低IgM相关; *血球菌*和*链球菌*扩张与无法检测的IgA和COPD有关.
结论:
- 患有CVID的患者呈现出扰乱的口腔菌群,其特点是潜在的致病性细菌的丰富和保护性物种的减少.
- 诸如低残留IgA/IgM,慢性肺损伤和抗生素预防等因素有助于CVID中的呼吸道失调.
- 在CVID患者中,口腔管微生物组的改变与急性呼吸道感染的风险增加有关.
关键词:
血球菌 (Haemophilus) 是一种血球菌.在 IgA A 里面.的IgM IgM 的情况.肺炎球菌是一種肺炎球菌.慢性阻塞性肺病 慢性阻塞性肺病常见的可变免疫缺陷常见的免疫缺陷.微生物组和失生菌病.耳鼻喉微生物群的微生物群更多相关视频
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