喘和心血管疾病之间的关联:使用国家健康查队列的纵向随访研究
Hyo Geun Choi1, Mi Jung Kwon2, Ji Hee Kim3
1Suseo Seoul E.N.T. Clinic and MD Analytics, Seoul, South Korea.
The World Allergy Organization journal
|June 14, 2024
概括
患有喘的成年人面临患心血管疾病 (CVD) 的风险更高,包括缺血性心脏病和心力衰竭. 严重的喘恶化进一步增加了这种心血管疾病风险.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 喘作为心血管疾病 (CVD) 风险因素的作用受到争论.
- 现有证据表明喘和心血管疾病之间存在联系,但缺乏确的发现.
研究的目的:
- 调查喘和心血管疾病 (CVD) 之间的长期关联.
- 探索喘恶化对特定心脏病发病率的影响,如缺血性心脏病 (IHD),心力衰竭 (HF) 和中风.
主要方法:
- 利用来自韩国国家医疗保险服务-健康查队列 (2002-2015) 的数据.
- 包括111,316名喘患者和同等数量的匹配对照.
- 员工倾向得分重叠加权重考克斯比例危险回归分析危险比率 (HRs).
主要成果:
- 与对照组相比,喘患者的IHD发病率 (每1000人年7.82比5.79) 和高血压 (2.53比1.36) 高于对照组.
- 调整后的分析显示,喘患者的IHD (1.27倍) 和HF (1.56倍) 的HR显著更高.
- 喘恶化与IHD (1.29倍) 和HF (1.68倍) 的HRs增加有关.
- 在喘患者中观察到中风发生率的减少 (aHR=0.96).
结论:
- 被诊断为喘的成年人患心血管疾病的可能性更高.
- 频繁或严重的喘恶化与心血管疾病发生的风险显著增加有关.
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