便供体查过程的经济和时间优化
Bar Levy1,2, Naomi Fliss Isakov1,2, Tomer Ziv-Baran1
1School of Medicine, Tel Aviv University, Tel Aviv, Israel.
MDM policy & practice
|June 14, 2024
概括
优化便微生物移植 (FMT) 供体查测试的顺序可以显著降低成本. 这种新算法可以节省高达50%的捐赠者查费用,使FMT更容易获得.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 卫生经济学 卫生经济学
背景情况:
- 便微生物移植 (FMT) 是复发性Clostridioides difficile感染的关键治疗方法.
- 供体查涉及多项昂贵的血液和便测试.
- 目前的选过程昂贵且耗时.
研究的目的:
- 开发和分析一个算法,以优化供体查测试的顺序.
- 为了最大限度地降低健康捐赠者获得FMT资格的总体成本.
主要方法:
- 设计了一个算法来确定选测试中最具成本效益的序列.
- 使用已发表的文献和现实世界的数据进行了性能分析.
- 根据优化测试顺序计算出供体资格的总成本.
主要成果:
- 根据文献数据,该算法显示,在查方面,潜在的成本节约高达94.2%,在整体资格方面则高达7.05%.
- 在现实世界的一组中,优化测试顺序导致大约49.9%的查成本和21.3%的资格成本节省.
- 在查过程中,大量的潜在捐赠者被取消资格.
结论:
- 对FMT捐赠者重新安排查测试可以大幅降低成本.
- 实施优化的查协议可以将每名受试者的费用降低约50%.
- 这种优化可以提高FMT程序的经济可行性.
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