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增加FGF2表达促进免疫细胞透,与甲状腺癌的不良预后相关

Han Chen¹, Xiaoyun Du¹

¹Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, China.

|June 14, 2024

概括

纤维细胞生长因子2 (FGF2) 在甲状腺癌 (THCA) 中过度表达,与生存率较差和免疫细胞透率增加相关. FGF2可以作为THCA患者的预后标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

甲状腺癌 (THCA) 是一个重要的全球健康问题.
了解驱动THCA进展的分子机制对于改善患者的治疗结果至关重要.

研究的目的:

研究甲状腺癌中纤维细胞生长因子2 (FGF2) 的表达,功能和预后价值.
在THCA患者中分析FGF2和免疫细胞透之间的关联.

主要方法:

使用了多个在线数据库 (UALCAN,人类蛋白质图谱,卡普兰-梅尔图谱器等). 进行全面分析.
检查了FGF2转录和蛋白质水平,甲基化和突变状态.
相关的FGF2表达与临床参数,预后和免疫细胞透使用统计分析和西方Blot.

主要成果:

在THCA组织中,FGF2显著过度表达,并且与年龄,组织学,结节转移和癌症阶段等临床因素相关.
较高的FGF2表达与较差的无复发生存率 (HR=3.42,p=0.00099) 相关,特别是在女性患者中.
增加的FGF2甲基化和突变与分别较差的无进展和无疾病生存率有关.
FGF2表达与B细胞,CD4+T细胞,巨细胞,中性粒细胞和树突细胞的透具有积极的相关性.
FGF2功能可能参与细胞粘附,细胞因子-细胞因子受体相互作用和血管生成.

结论:

FGF2是甲状腺癌的潜在预后生物标志物.
过度表达FGF2,改变甲基化和突变与THCA的不良临床结果有关.
通过其在细胞粘附,血管生成和瘤免疫微环境调节中的作用,FGF2可能会影响THCA进展.

关键词:

生物信息学是一种生物信息学.在FGF2上.免疫细胞的透.预测预测预测预测的时间.甲状腺癌是什么?甲状腺癌是什么?

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