未成熟粒细胞与类风湿性关节炎疾病活性之间的关系
Nurten Seringec Akkececi1, Muhammed Ciftcioglu2, Burak Okyar3
1Department of Physiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
International journal of rheumatic diseases
|June 14, 2024
概括
新的炎症标志物,IG计数 (IG#) 和IG百分比 (IG%),与类风湿性关节炎 (RA) 疾病活动有很强的关联. 这些标记可以帮助监测RA,并作为可访问的诊断工具.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床化学 临床化学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
- 精确监测疾病活动和早期诊断对于有效的RA管理至关重要.
研究的目的:
- 调查IG计数 (IG#) 和IG百分比 (IG%) 与类风湿性关节炎 (RA) 疾病活性之间的关联.
- 评估IG#和IG%作为RA的诊断生物标志物的潜力.
主要方法:
- 一项涉及65名RA患者和65名健康对照者的回顾性研究.
- 使用疾病活动评分28 (DAS28),临床疾病活动指数 (CDAI) 和简单疾病活动指数 (SDAI) 评估疾病活动.
- 用于确定诊断价值的接收器-操作员特征 (ROC) 曲线分析.
主要成果:
- 与健康对照组相比,活跃的RA患者的IG#和IG%水平显著升高.
- 这些标志物在缓解后显著下降,并且与疾病活性指数 (DAS28,CDAI,SDAI) 和炎症标志物 (ESR,CRP) 有积极的相关性.
- 在RA检测中,ROC分析表明IG#和IG%具有显著的诊断价值 (AUC0.8530.865).
结论:
- IG计数和IG百分比是监测类风湿性关节炎疾病活动的有价值的炎症标志物.
- IG#和IG%作为RA的快速,廉价和可访问的补充诊断标记.
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