与多药耐药结核病相关的危险因素在具有中度结核病负担的地区
Noormohamad Mansoori1, Bagher Pahlavanzadeh2, Masoumeh Atarjalali3
1Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran.
International health
|June 14, 2024
概括
多药耐药结核病 (MDR-TB) 影响伊朗北部2.5%的患者. 风险因素包括婚姻状况,性别和先前的治疗,需要改进的坚持策略.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 耐多药结核病 (MDR-TB) 和耐利素 (RR) 结核病对全球健康构成挑战.
- 有效的结核病控制需要了解当地的耐药性模式和风险因素.
研究的目的:
- 为了估计伊朗北部MDR-/RR-TB的发病率.
- 为了确定与MDR-/RR-TB发病率相关的风险因素.
主要方法:
- 使用Lowenstein-Jensen媒介上的比例方法进行药物敏感性测试.
- 从伊朗结核病登记处收集的人口和临床数据.
主要成果:
- 在1083名结核病患者中,有2.5%患有MDR-/RR-TB,6.7%患有任何药物耐药性 (ADR).
- 在婚姻状况和MDR-/RR-TB之间发现了显著的关联 (p=0.003).
- ADR-TB与性别 (p=0.035) 和先前的结核病治疗 (p=0.02) 有显著的关联.
结论:
- 调查结果突出了Mycobacterium结核病耐药性模式和伊朗北部的危险因素.
- 需要创造性的方法来提高治疗的坚持,特别是对于离婚/丧偶的妇女和那些先前接受过结核病治疗的人来说.
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