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Updated: Jun 24, 2025

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

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Azacryptands的结构优化用于针对三向DNA连接的目标.

Angélique Pipier1, Titouan Chetot2, Apollonia Kalamatianou2

  • 1Institut de Chimie Moléculaire, ICMUB CNRS UMR6302, 9, Avenue Alain Savary, 21078, Dijon, France.

Angewandte Chemie (International ed. in English)
|June 14, 2024
PubMed
概括

研究人员确定了新型的azacryptands,TrisNP-amphi和TrisNP-ana,作为高亲和度,选择性三向DNA结 (TWJs) 的配体. 这些分子为癌症治疗和理解TWJ在基因组稳定中的作用提供了新的工具.

关键词:
接口 接口 DNA 接口 DNA 接口这就是NMR的NMR.在体外测定试验 (in vitro assays)结合物 结合物 结合物 结合物分子动力学分子动力学

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DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
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