长期的特杜格卢类药物与小儿短肠综合征相关肠衰竭的改善反应有关
Paul W Wales1, Susan Hill2, Ian Robinson3
1Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.
Journal of pediatric gastroenterology and nutrition
|June 14, 2024
概括
在96周的时间里,泰杜格卢提德显著降低了儿科患者与短肠综合征相关的肠衰竭的亲肠营养/静脉输液需求. 反应预测因素包括肠道解剖学,人口统计和治疗持续时间.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
- 父母肠道营养是一种营养.
背景情况:
- 短肠综合征相关的肠衰竭 (SBS-IF) 需要长期的肠外营养/静脉输液 (PN/IV).
- 泰杜格卢提德是SBS-IF的潜在治疗剂.
研究的目的:
- 评估泰杜格卢胺在患有SBS-IF的儿科患者的长期安全性和疗效.
- 为了识别96周内特杜格卢类药物反应的预测因素.
主要方法:
- 两项开放标签,长期延伸研究的综合分析.
- 评估治疗出现的不良事件和临床反应 (PN/IV体积≥20%减少).
- 多变量线性回归确定了PN/IV体积减少的预测因素.
主要成果:
- 82.1%的接受泰杜格胺治疗的患者在96.6周内获得了临床反应.
- 平均PN/IV体积显著减少 (30.1毫升/千克/天液体,21.6千卡/千克/天能量).
- 反应的预测因素包括结肠连续性,非白人种族,年龄较大,暴露时间较长和剩余的小肠长度.
结论:
- 泰杜格卢提德可以长期减少儿科SBS-IF的PN/IV需求.
- 反应受治疗持续时间,肠道解剖学和患者人口统计学的影响.
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