相关实验视频
Updated: Jun 24, 2025

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.6K
分化高度甲状腺癌的细胞学特征:对40例病例的多机构研究
Vanda F Torous1, Tikamporn Jitpasutham1,2, Zubair Baloch3
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
Cancer cytopathology
|June 14, 2024
概括
分化高度甲状腺癌 (DHGTC) 往往缺乏明显的细胞学特征,使得诊断具有挑战性. 然而,特定的细胞形态学,分子变化和临床病理学因素可能表明这种侵袭性癌症.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 细胞病理学 细胞病理学
背景情况:
- 分化高度甲状腺癌 (DHGTC) 是一种独特的实体,在分化良好的瘤中具有高度特征.
- 由于DHGTC的细胞形态学尚未很好地确立,这影响了临床管理和患者选.
研究的目的:
- 在精细针吸收 (FNA) 样本中记录DHGTC的细胞形态特征.
- 将细胞学发现与组织学亚型,分子变化和临床病理学特征相关联.
主要方法:
- 根据世界卫生组织 (WHO) 标准诊断的40例先前FNA的DHGTC病例的回顾性审查.
- 在FNA样本中评估了32个细胞形态特征.
- 分析相应的组织学,分子变化和临床病理学数据.
主要成果:
- 超过97%的DHGTC FNA病例是贝塞斯达类别IV或更高的.
- 大约25%的DHGTCs表现出细胞性异型,核大小增加,线粒活动或亡.
- 68%的DHGTC病例显示出高风险的分子变异,经常是TERT突变与RAS或BRAF突变相结合.
结论:
- 细胞学对诊断DHGTC的敏感性有限.
- 某些细胞学特征,以及临床病理学指标,如年龄较大和病变大小较大,可以引起对DHGTC的怀疑.
- 高风险的分子变化在DHGTC中很常见.
相关概念视频
The Thyroid Gland
3.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.8K
Cellular Differentiation
2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.6K

