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断片查以识别向石加毒素2的核糖体结合的抑制剂

Michael J Rudolph1, Anastasiia M Tsymbal2, Arkajyoti Dutta3

  • 1New York Structural Biology Center, 89 Convent Ave, New York, New York 10027, United States.

ACS infectious diseases
|June 14, 2024
PubMed
概括

研究人员发现了新的小分子,通过结合它的核糖体位来准Shiga毒素2 (Stx2A1). 这些化合物提供了一种有前途的新疗法策略,用于对抗产生Shiga毒素的大肠杆菌感染.

关键词:
石加毒素是一种毒素.在X射线中,晶体结构是X射线.抑制了排尿的抑制作用.基于碎片的药物发现.核糖体结合 核糖体结合核糖体失活蛋白质是一种核糖体失活蛋白质.

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Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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