博森坦和COVID-19引起的肺高血压:一个试点随机双盲临床研究
Fahime Shokrollahi1, Ali Pazoki1, Abbas Allami1
1Clinical Research Development Unit, BouAlisina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Current vascular pharmacology
|June 14, 2024
概括
博森坦降低了COVID-19肺高血压 (PH) 患者的住院死亡率,并改善了心声图测量. 然而,它与长期死亡率和氧气需求的增加有关,需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19可能会导致严重的并发症,如肺高血压 (PH).
- 结末素-1 (ET-1) 受体对抗剂,如博森坦,可以治疗与PH相关的ET-1水平升高.
- 调查博森坦在COVID-19引起的PH中的疗效至关重要.
研究的目的:
- 评估博森坦在COVID-19引起的PH患者的治疗效果.
- 评估博森坦对该患者群的死亡率和心声学参数的影响.
主要方法:
- 一项随机,双盲,单中心的研究,共72名参与者 (36名博森坦,36名安慰剂).
- 心声学被用来测量肺动脉压力,三管压力梯度和右心房压力.
- 考克斯比例危险回归分析了6个月的随访期间的死亡率.
主要成果:
- 住院死亡率在博森坦组 (13%) 与安慰剂 (33.3%) (P=0.003) 相比显著较低.
- 博森坦改善了缩性肺动脉压力和三回梯度 (P=0.011,P=0.003).
- 博森坦使用预测了更高的长期死亡率 (年龄调整后的危险比率为5.24).
结论:
- 博森坦在与COVID-19相关的PH中表现出混合作用,减少住院死亡率和改善心声测量.
- 然而,博森坦治疗与增加补充氧气需求和长期死亡率有关.
- 需要进一步的大规模研究来澄清博森坦在COVID-19后的PH管理中的作用.
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