系统性红斑狼和牛皮关节炎的不常见共存:基于案例的审查
Aliki I Venetsanopoulou1, Ioanna Katsigianni2, Elpida Skouvaklidou2
1Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Current rheumatology reviews
|June 14, 2024
概括
同时发生的系统性红斑狼 (SLE) 和牛皮关节炎 (PsA) 是罕见的. 介素-17A对这两种疾病都有影响,因此需要个性化治疗和对患有这两种自身免疫性疾病的患者进行仔细监测.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性红斑狼 (SLE) 和牛皮性关节炎 (PsA) 的同时发生并不常见.
- 由于疾病的复杂性和罕见性,关于SLE-PsA共存的全球数据有限.
- 同时存在的SLE和PsA的病理生理学,特别是17A介质素的作用,仍然不太了解.
研究的目的:
- 报告7例SLE和PSA同时存在的病例.
- 审查有关这两种自身免疫性疾病的共存现有的文献.
- 突出治疗挑战和个性化管理的重要性.
主要方法:
- 一系列病例报告了七名患有同时存在SLE和PsA的患者.
- 对SLE-PsA共存研究的文献综述.
- 对疾病呈现,进展和治疗反应的分析.
主要成果:
- 在5/7的病例中,PSA先于SLE;在2/7的病例中,SLE先于PSA.
- 主要呈现为外周关节炎,没有轴性干涉.
- SLE的表现有所不同,三名患者患有严重的全身性疾病.
- 治疗带来了挑战,治疗另一种疾病可能会使一种疾病恶化.
结论:
- SLE和PsA的共存带来了独特的临床和治疗挑战.
- 介素-17A可能在这两种疾病的进展中发挥重要作用.
- 个性化治疗策略和警监测对于管理患有SLE和PSA的患者至关重要.
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