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病毒诱导的希斯乳化促进了类动物的病毒感染

Yu Zhang^1,2, Xiaobo Zhang^1,3,4

¹College of Life Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|June 14, 2024

概括

在中感染白斑综合征病毒 (WSSV) 会促进糖解,增加乳酸. 这种乳酸促进了基因乳化,增强了病毒复制,但病毒微RNA (miR-N20) 抑制了这一过程.

科学领域:

病毒学病毒学
分子生物学分子生物学
生物化学生物化学

背景情况:

病毒作为非细胞生物,依赖宿主细胞生存,改变宿主新陈代谢.
病毒诱导的代谢变化对病毒与宿主相互作用的影响尚未完全理解.
了解这些相互作用对于开发抗病毒策略至关重要.

研究的目的:

研究宿主代谢物在病毒与宿主相互作用中的作用.
为了阐明病毒诱导的基因素乳酸化机制.
为了确定控制WSSV感染的潜在目标.

主要方法:

在体内,挑战带有白斑综合征病毒 (WSSV).
分析代谢变化,特别是糖解和乳酸积累.
评估基因组乳化 (H3K18la,H4K12la) 和基因表达.
研究病毒微RNA (miR-N20) 和HIF-1α的作用.

主要成果:

感染WSSV增强了的糖解,导致乳酸的积累.
乳酸盐通过p300/HDAC1/HDAC3促进了基因组乳化 (H3K18la,H4K12la),上调了S6K2的表达,促进了病毒感染.
病毒miR-N20向HIF-1α,抑制糖解和抑制组织蛋白乳酸化.

结论:

病毒诱导的组素乳化是病毒与宿主相互作用的关键机制.
代谢变化,特别是乳酸积累,在促进病毒感染方面发挥着重要作用.
向激素乳化或相关途径为抗病毒疗法提供了一种新的方法.

关键词:

葡萄糖溶解是什么基因素乳酸化基因素乳酸化代谢物的代谢物.这是一个小RNARNA.病毒感染病毒感染

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