早期局部使用mitomycin-C可以防止儿童的狭窄形成,有腐蚀性摄入
Happy Sawires1, Ayman Aeskander2, Manal El-Sayed1
1Pediatric Department, Cairo University, Giza, Egypt.
Journal of paediatrics and child health
|June 14, 2024
概括
早期局部应用的米托米辛C (MMC) 显著减少食道狭窄在儿童后腐蚀性摄入. 这种治疗被证明是安全和有效的,与传统管理相比,减少了扩张的需要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 毒理学 毒理学 毒理学
背景情况:
- 儿童因果性摄入经常导致食道狭窄,这是一个常见的长期并发症.
- 目前的管理往往涉及重复的内镜扩张,这可能是繁的和不太有效的.
研究的目的:
- 评估早期局部内镜应用米托米辛C (MMC) 的疗效和安全性,以预防儿科患者在有毒摄入后的狭窄形成.
主要方法:
- 一项前性随机对照研究包括78名近期摄入有毒物质的儿童;61人完成了这项研究.
- 组A (30名儿童) 在48小时内接受了局部MMC,而组B (31名儿童) 接受了常规管理.
- 根据需要,两组都接受了随访内镜扩张.
主要成果:
- 在接受早期MMC治疗的儿童中,只有30%的儿童出现了收缩,而在常规治疗组中,这一比例为100% (P < 0.001).
- 在MMC组需要零中位扩张,而在常规组26 (P<0.001).
- 早期的MMC应用实现了86.7%的完全响应率,明显高于传统治疗 (35.5%).
结论:
- 早期局部应用mitomycin C是一种有效和安全的策略,用于预防食道狭窄和痕形成在儿童腐蚀性摄入后.
- 这种方法减少了后续内镜干预的需要.
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