在桃体切除术后控制疼痛的雾化与静脉注射芬太尼的比较分析:双盲,随机,受控试验
Chanitda Pantabtim1, Saowapark Chumpathong1, Phongthara Vichitvejpaisal1
1Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
The Annals of otology, rhinology, and laryngology
|June 14, 2024
概括
与静脉注射芬太尼相比,雾化芬太尼在桃体切除术后提供更长的疼痛缓解. 这项研究发现,雾化芬太尼提供了延长的止痛,具有类似的发病和副作用概况,这表明它是桃体切除术后疼痛管理的可行替代方案.
科学领域:
- 麻醉学和疼痛管理
- 药理学 药理学是指药理学的学科.
- 术后恢复 术后恢复
背景情况:
- 桃体切除术后有效的疼痛管理对于患者的康复至关重要.
- 芬太尼是一种强效的止痛药,但其雾化形式用于桃体切除术后的疼痛是研究不足的.
- 这项研究研究了雾化与静脉注射芬太尼的治疗桃体切除术后疼痛.
研究的目的:
- 为了比较 nebulized fentanyl 与静脉注射 fentanyl 的止痛效果.
- 为了评估两种施用途径的疼痛缓解的开始时间.
- 评估和比较与每种芬太尼尔施用方法相关的并发症发生率.
主要方法:
- 一项随机对照试验,涉及接受桃体切除术的成年患者.
- 当疼痛分数超过3.0时,患者接受了静脉注射芬太尼 (1毫克/千克) 或雾化芬太尼 (4毫克/千克).
- 疼痛水平,下一次止痛要求的时间和并发症都被监测了24小时.
主要成果:
- 雾化剂组在需要下一次止痛之前经历了显著更长的持续时间 (IV组的中位数为683.5分钟,IV组为326.7分钟,P=.009).
- 两组之间没有观察到足够控制疼痛的时间 (疼痛分数<4) 显著差异.
- 副作用的发生率,包括呼吸抑制和恶心,在雾化和静脉注射芬太尼群体中都相似.
结论:
- 与静脉注射芬太尼相比,雾化芬太尼在桃体切除术后的疼痛中提供更长时间的止痛效果.
- 发病时间和副作用概况在雾化和静脉注射芬太尼之间是可比的.
- 雾化芬太尼为有效的桃体切除术后疼痛管理提供了一个有希望的替代方案.
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