基路特征对治疗有效性的影响:系统性审查
Vazula Bekkers1, Paul Barsoum2, Qi Yin2
1Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
概括
凯洛伊德治疗的有效性各不相同. 较老,较大或在特定的身体部位出现反复发生的状体显示治疗效率降低. 需要进一步的研究来分类 keloids 和指导基于证据的治疗.
科学领域:
- 皮肤病学 皮肤病学
- 临床试验 临床试验
- 基于证据的医学基于证据的医学.
背景情况:
- 随机研究中的基洛因治疗疗效不一致.
- 没有系统性审查评估了 keloid 特性如何影响治疗结果.
研究的目的:
- 为了确定影响治疗疗效的关键化物特性.
- 为了指导未来的研究和临床实践对 keloid 管理.
主要方法:
- 随机对照试验 (RCT) 的系统审查.
- 电子数据库搜索和两个审稿人的独立选择.
- 使用Cochrane偏差风险2.0工具进行方法质量评估.
主要成果:
- 包括16个涉及1113名患者的RCT.
- 对于较老,较大,反复出现的状体,以及胸部,四肢,部和肩膀上的状体,观察到较低的疗效.
- 大多数纳入的研究都表现出高偏差风险.
结论:
- 状体的位置,持续时间,大小,复发史和严重程度显著影响治疗的有效性.
- 关于 keloid 属性的有限数据阻碍了直接比较.
- 进一步的研究对于开发 keloid 分类和基于证据的治疗算法至关重要.
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