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脑下深层大脑刺激对帕金森病患者的冷漠的影响
Ozge Gonul Oner1, Shabnam Jafarova, Hatice Ozden
1Marmara University Pendik Research and Training Hospital Department of Neurology, Istanbul, Türkiye.
Turkish neurosurgery
|June 14, 2024
概括
亚thalamic深度大脑刺激 (STN DBS) 在帕金森病 (PD) 患者中没有显著影响冷漠. 减少手术后的多巴胺作用药物可能有助于预防冷漠的增加.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
背景情况:
- 漠不关心是帕金森病 (PD) 的一个常见的非运动症状.
- 脑下深层大脑刺激 (STN DBS) 是高级PD的治疗选择.
- 对STN DBS对冷漠的影响需要进一步调查.
研究的目的:
- 评估STN DBS对PD患者无动于衷的影响.
- 在STN DBS后探索冷漠,抑郁和莱沃多巴等效剂量 (LED) 之间的关系.
主要方法:
- 26名PD患者在STN DBS之前和6个月后接受了评估.
- 评估包括统一的帕金森病评分表 (UPDRS),贝克抑郁症库存 (Beck D),贝克焦虑库存 (Beck A),蒙特利尔认知评估 (MoCA) 和帕金森病问卷 (PDQ-39).
主要成果:
- 无动于衷的得分显示STN DBS后的无意义下降 (p=0.502).
- 无动于衷的变化与UPDRS,贝克D或贝克A分数之间没有发现显著的相关性.
- 在冷漠度得分变化和莱沃多巴等效剂量 (LED) 之间观察到非显著的负相关性.
结论:
- STN DBS不会对PD患者的冷漠产生负面影响.
- 在STN DBS后保守地减少多巴胺作用药物可能对防止冷漠性增加至关重要.
- 需要进一步的研究,以了解STN DBS,多巴胺疗法和PD中的冷漠之间的复杂相互作用.
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