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CD117的负表达预测了急性前兆细胞白血病中劣质的OS和PFS

Hui Zeng¹, Jie He¹, Hai-Bo Dong¹

¹Department of Hematology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

International journal of laboratory hematology

|June 14, 2024

概括

在接受全转录氨酸酸和三氧化治疗的急性前列细胞白血病 (APL) 患者中,负的CD117表达与更高的早期死亡风险和更差的生存结果有关. 这一发现表明CD117状态可以帮助APL管理的风险分层.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫型定型免疫型定型

背景情况:

确立了CD117抗原在血液性恶性瘤中的预后作用.
关于CD117在急性肌肉细胞白血病 (APL) 中的临床意义的数据有限.

研究的目的:

调查APL中负CD117表达的临床特征和预后影响.
分析APL患者的结局,这些患者接受过全转网红酸 (ATRA) 和三氧化 (ATO) 治疗.

主要方法:

对169名APL患者的回顾性分析.
基于CD117表达状态 (CD117+与CD117-) 的临床病理特征和结果的评估.
多变量分析以确定总生存期 (OS) 和无进展生存期 (PFS) 的预后因素.

主要成果:

在7.7%的APL患者中观察到负CD117表达 (CD117-).
与CD117+APL相比,CD117-APL显示早期死亡 (ED) 的发生率显著更高.
CD117-被确定为OS和PFS的独立不良预后因素.

结论:

CD117的表达与APL中ED的风险增加有关.
CD117状态显示了预测劣质OS和PFS的统计能力.
CD117可以纳入风险适应的APL治疗策略的预后得分.

关键词:

在AML,AML就是AML.

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