在抑郁症中使用催眠药的趋势2007-2017:瑞典基于人口的研究
Adam Nygren1, P Brenner1,2, L Brandt1
1Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
Journal of sleep research
|June 14, 2024
概括
抑郁症患者的催眠药物使用在2007-2017年期间仍然很高,Z型药物处方下降,黑激素使用显著增加. 这种趋势甚至在诊断后的三年内仍然存在.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 失眠是抑郁症的常见症状,但治疗指导方针对催眠药物治疗提供了有限的指导.
- 对抑郁症患者使用催眠药物的研究很少.
研究的目的:
- 调查从2007年到2017年在瑞典诊断为单极抑郁症的患者中使用催眠药物的流行率和趋势.
主要方法:
- 一项使用瑞典国家登记册的队列研究,包括222,077名年龄在18岁以上,患有单极性抑郁症的患者.
- 随访3年,分析每年和每季度的催眠药处方填充.
- 计算了流行率 (PR),以比较2017年与2007年的情况.
主要成果:
- 在诊断后的一年,催眠使用率在2017年为44.1%,而在2007年为46.7% (PR 0.94).
- Z型药物使用率从2007年的35.6%降至2017年的27.6% (PR 0.78),而黑激素使用率则从0.4%上升至12.0% (PR 28.9).
- 诊断后早期的催眠使用率最高,但在3年后仍为19.2%;女性,老年患者,并患有并发症或严重抑郁症的人群使用率更高.
结论:
- 在瑞典,催眠药在抑郁症治疗中被广泛使用.
- 从Z类药物转向黑色素发生了显著的转变,黑色素的使用量急剧增加.
- 持续使用催眠药物,即使是长期使用,也突出了抑郁症管理中的重大临床问题.
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