基于ARG推断的历史人口大小偏见在经历选择的人口中的偏见
Jacob I Marsh1, Parul Johri1,2,3
1Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Molecular biology and evolution
|June 14, 2024
概括
人口历史的祖先重组图 (ARG) 方法对人类来说很强大,但可以通过对Drosophila melanogaster等物种的选择来误导. 仅仅背景选择可以导致对人口扩张的不准确推断.
科学领域:
- 人口遗传学 人口遗传学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 推断种群历史是理解物种动态和选择过程的关键.
- 选择的链接效应可以创建模仿或掩盖人口信号的基因组签名.
- 使用基于祖先重组图 (ARG) 的方法对人口推断的选择的影响尚未完全理解.
研究的目的:
- 通过基于ARG的方法评估链接选择对人口推断的影响.
- 在各种选择场景下,评估人类和Drosophila melanogaster种群的人口推断的准确性.
主要方法:
- 开发了现实的前模拟,包括基因密度,突变,重组和选择.
- 在不同的历史人口统计情景下,模拟人类和Drosophila melanogaster种群.
- 应用基于ARG的方法,从模拟数据中推断出人口史.
主要成果:
- 链接选择在模拟人类群体中对人口推断的影响最小.
- 仅仅背景选择就损害了模拟D. melanogaster种群的精确人口统计推断,导致虚假的扩张信号.
- 根据突变特征,反复的扫描可能会进一步加剧D. melanogaster的误导作用.
结论:
- 基于ARG的人口推断通常对人类人口来说是可靠的.
- 在向非人类群体应用基于ARG的方法时,建议谨慎使用,特别是那些具有高反复选择率的人群.
- 建议进行特定物种的模拟,以验证非人类物种的人口推断.
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