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Updated: Jun 23, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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在真核细胞中,图书馆辅助的进化产生了具有增强编辑特异性的腺基编辑器

Shenlin Hsiao1, Shuanghong Chen1, Yanhong Jiang1

  • 1Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 14, 2024
PubMed
概括

研究人员使用真核细胞开发了新的腺基编辑器 (ABE) 变体. 这些改进的ABE工具为治疗应用提供了精确的基因编辑,具有更高的特异性,并减少了目标外影响.

关键词:
腺基编辑器 腺基编辑器图书馆辅助的进化研究.精确的基因编辑.

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