童年,青春期和中年期的认知功能与DNA甲基化的关联中年期的年龄加速
Junyu Chen1, Leah Moubadder1, Elizabeth S Clausing1,2
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Aging
|June 14, 2024
概括
青春期和中年期的认知功能与生物衰老加速有关,特别是结晶和流体智力. 早期儿童的认知没有显示出与中年衰老加速的显著关联.
科学领域:
- 表观遗传学和衰老的研究
- 认知神经科学 认知神经科学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,在老年人中,加速的生物衰老和认知功能下降之间存在相关性.
- 不同生命阶段的认知发展与表观遗传衰老标志物之间的关系仍然不完全理解.
研究的目的:
- 研究童年,青春期和中年期的认知表现与中年期衰老加速 (AgeAccel) 的各种表观遗传测量之间的关联.
- 探索结晶和流体智能对生物衰老过程的影响.
主要方法:
- 利用了359名参与者的数据,从童年到中年进行认知评估,以及中年DNA甲基化 (DNAm) 数据.
- 从DNAm.PACE中计算了多个AgeAccel测量 (Horvath,Hannum,PhenoAge,GrimAge,DunedinPACE) 的时间.
- 使用线性回归模型,调整混因子,分析认知功能和AgeAccel关联.
主要成果:
- 在童年认知和中年之间没有发现任何显著的关联.
- 青少年结晶智力 (皮博迪图片词汇测试) 显示了与GrimAge的适度反向关联,由社会经济地位减弱.
- 中年结晶智能 (成人阅读的韦克斯勒测试) 和流体智能 (数字符号) 分别与PhenoAge和GrimAge负相关.
结论:
- 认知功能,特别是青春期和中年期的结晶和流动智力,可能与生物衰老加速有关.
- 这项研究强调了认知轨迹在生物衰老过程中的作用,并提出了干预的潜在目标.
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