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Updated: Jun 23, 2025

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晚期脱硫能够快速有效地合成抗体-药物结合物的甲素-可裂解链接剂的固体相

Marzieh Ahangarpour1,2, Margaret A Brimble1,2,3, Iman Kavianinia2,3

  • 1School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland 1010, New Zealand.

Bioconjugate chemistry
|June 14, 2024
PubMed
概括

这项研究引入了一种新的,具有成本效益的方法,用于合成抗体-药物合物 (ADC) 的甲素B可切割链接剂. 这种新方法使用后期脱硫化学,以改善瘤药物开发中的链接物合成.

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Phase II Reactions: Sulfation and Conjugation with α-Amino Acids01:19

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Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme...
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