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微生物殖民在部分暴露的非吸收性膜在膜脊保护期间
Silvia Helena Garcia Braz1, Mabelle Freitas Monteiro2, Edson Ken Matumoto1
1Dental Research Division, School of Dentistry, Paulista University, Av. Dr. Bacelar, 1212, 4° andar, Vila Clementino, São Paulo, 04026-002, SP, Brazil.
Clinical oral investigations
|June 14, 2024
概括
部分暴露的EPTFE膜用于膜脊保护 (ARP) 改变了微生物殖民,有利于无氧细菌. 需要进一步的研究来管理这些暴露膜部位的生物膜形成.
科学领域:
- 在口腔外科手术中.
- 牙周病学 牙周病学
- 微生物学 微生物学
背景情况:
- 膜脊保护 (ARP) 对于在拔牙后保持骨体积至关重要.
- 不能吸收的膜,如扩展聚四乙烯 (dPTFE),在ARP中用于指导骨再生.
- 蓄意将这些膜暴露在口腔环境对微生物殖民的影响尚未完全理解.
研究的目的:
- 为了评估部分暴露的dPTFE膜在膜脊保存期间对微生物殖民的影响.
- 为了比较用暴露的dPTFE膜处理的部位中的微生物组合,与无助的插座愈合相比.
主要方法:
- 一项随机对照试验,涉及接受牙拔牙的患者.
- 两个组:dPTFE组 (暴露膜用于ARP) 和USH组 (无助口愈合).
- 使用Illumina MiSeq.在3天和28天采集的生物膜样本的微生物组分析.
主要成果:
- 在小组之间和随着时间的推移,观察到微生物群体组成 (β多样性) 的显著差异.
- 与USH组相比,dPTFE组显示出更高的格拉姆阴性和无氧细菌的流行率和丰度.
- 不同的微生物群落殖民了dPTFE膜的内外表面.
结论:
- 蓄意暴露的dPTFE膜调节ARP地点的微生物环境,促进一个更无氧和均的社区.
- dPTFE膜促进了更快的生物膜殖民化,丰富了格拉姆阴性和无氧物种.
- 虽然可以使用暴露的dPTFE膜,但对生物膜控制的策略需要考虑.
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