标记性肥胖症和癌症患者的结果
Chenan Liu1,2,3,4, Tong Liu1,2,3,4, Li Deng1,2,3,4
1Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
JAMA network open
|June 14, 2024
概括
癌症患者的sarcopenic肥胖 (SO) 与更糟糕的生存率和生活质量有关. 低握力是唯一与整体生存相关的SO成分,突出了ESPEN-EASO标准.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 代谢过程中的代谢.
背景情况:
- 皮性肥胖症 (SO) 是一种由皮症和肥胖症同时发生的疾病.
- 欧洲临床营养和新陈代谢学会 (ESPEN) 和欧洲肥胖研究协会 (EASO) 已经为SO. 确立了诊断标准.
- 在患有固体瘤的患者中,SO的临床影响仍然不完全理解.
研究的目的:
- 实施ESPEN-EASO诊断算法来诊断型肥胖症.
- 为了确定固体瘤患者中SO的患病率.
- 调查SO与整体存活率 (OS),生活质量 (QoL) 和重症监护室 (ICU) 入院风险的关联.
主要方法:
- 一项前性队列研究,包括6790名患有固体瘤的患者.
- 根据ESPEN-EASO标准,患者被归类为SO或非SO.
- 评估的结果包括OS,QoL和ICU入院,使用Cox回归和后勤回归进行分析.
主要成果:
- 肥胖症的患病率在整体队列中为4.36%,在肥胖子组中为14.98%,随年龄增长而增加.
- SO独立地与较低的OS (HR,1.54) 相关,较差的QoL,以及增加了ICU入院风险 (OR,2.39).
- 手握强度低 (HGS) 是唯一与糟糕的操作系统相关的SO组件 (HR,1.15).
结论:
- 肥胖症是固体瘤癌症患者的显著临床并发症,与不良结果相关.
- 该ESPEN-EASO标准提供了一个实用的工具来识别SO在这个人群中.
- 早期识别和治疗SO可能对改善患者的预后和生活质量至关重要.
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